Sunday, November 25, 2012

Glossary for the Thyroid series

Blood Tests - The only blood tests, from a thyroid point of view, that you should be focussing on are Free T3 (FT3), Reverse T3 (RT3) and the Thyroid-antibodies: anti-TPO and TgAb  - a full list of recommended blood tests can be found here http://www.stopthethyroidmadness.com/recommended-labwork/  Furthermore, the thing to remember about thyroid blood tests is that thyroid operates primarily in the muscles and tissue, not the blood stream - and there's no conclusive way to check what's going on where thyroid operates other than symptoms.

Low Dose Naltrexone - http://restormedicine.com/low-dose-naltrexone-san-diego/ The best immune modulating agent out there for things like Hashimotos and Fybromyalgia - unfortunately the research is at an early stage but annecdotally a lot of Hashimotos patients and Fybromyalgia patients are seeing benefits see - http://snapl.stanford.edu/research/ldn.html

RT3 - Reverse triiodothyronine http://en.wikipedia.org/wiki/Reverse_triiodothyronine - your body, if it feels under threat in some way, can produce this hormone which locks on to the cell site in your body for T3 and instead of turning the cell on, turns it off. Unfortunately mitochondria do not come with flicky switches and once turned off, may not turn on, thus the problem can cascade.

T1 and T2 -  monoiodothyronine (T1) http://en.wikipedia.org/wiki/3'-Monoiodothyronine and diiodothyronine (T2) http://en.wikipedia.org/wiki/3,3'-Diiodothyronine are the most unstable of the thyroid hormones.  The nomenclature basically refers to the number of iodine molecules attached - 1-4.  Not a great deal is known about what either do, although both pass the blood-brain barrier and have functions in the brain.  T2 in particular has a role in regulating cellular energy production.  The only way to be supplemented with them is to take decicated pig thyroid, such as Armor, but T3 should break down into enough of T1 and T2 so long as you have a plentiful supply.

T3 - triiodothyronine http://en.wikipedia.org/wiki/Triiodothyronine is the primary active form of thyroid and is critical that you are primarily supplemented with T3 if you need supplementation. T3 is the master hormone - "it affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate." Most critical is its role in replication and gene expression. If you don't have enough of this, however high your T4 level, you will feel awful.  The problem with T3 is that it has a half life in the body of about 6 hours so you need to take it in a slow release form, or staged through the day (latter not being ideal).

T4 - Thyroxine http://en.wikipedia.org/wiki/Thyroxine - is the storage form of thryoid hormone.  Your organs can store it and convert it into T3.  A normal thyroid produces roughly 80% T4 and about 20% T3, but the TSH biofeedback loop can change that ratio, and also drive conversion of T4 into T3, but once you lose your thryoid that feedback loop gets broken. 

TSH - a brain chemical which responds to the level of T4 in the blood.  The blood test is really not very useful other than as a rough guide in diagnosis. http://www.stopthethyroidmadness.com/tsh-why-its-useless/

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